The speed, convenience and efficiency of detectors based on a CCD chip coupled to a primary conversion phosphor via a fibre optic taper have led to such systems being currently the most widely adopted at macromolecular crystallography beamlines (Tate et al., 2006 ▸ Minor et al., 2000 ▸). Developments in X-ray detection technologies have been spurred on by the proliferation of beamlines at large-scale third-generation synchrotron radiation sources, demanding large-area high-speed detectors. Many different types of two-dimensional area detector have been produced, including film, image plates, and various configurations of detectors based on CCD and CMOS sensors. The typical setup for macromolecular X-ray crystallography uses a large two-dimensional area detector to record accurately the positions and intensities of the diffraction spots.
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