![]() ![]() Over a mean of 26 years of follow-up, the numbers of major and total CVD events were not statistically different in Q4 compared with Q1-3 of either the INT or CONV group. The Q4 INT group experienced greater proportional weight gain (median change in BMI, 6.08 kg/m 2), increases in CVD risk factors, and need for medications for hypertension and lipids compared with the Q1-3 INT and comparable CONV groups. Effects of this weight gain on CVD risk factors and outcomes during an additional 20 years of observational follow-up were then determined. ![]() ![]() CONV) using change in BMI from baseline to the closeout DCCT visits. ![]() Quartiles (Q) of weight gain in 1,213 participants aged 18 years and older at enrollment in the Diabetes Control and Complications Trial (DCCT) were determined within randomized treatment groups (INT vs. Our objective was to examine whether excessive weight gain from INT of type 1 diabetes is independently associated with subsequent CVD events. Intensive treatment (INT) of type 1 diabetes reduces the incidence of cardiovascular disease (CVD) events compared with conventional treatment (CONV), but it also results in more weight gain. ![]()
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June 2023
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